The Bell Group: Single Molecule and Super-Resolution Fluorescenc

Keep Scrolling for our lab updates!

Sat, 05 May 2018 00:00:00 +1000

Keep Scrolling for our lab updates!

Ash and Tom doing the SMLM-AFM thing!

Tue, 02 May 2017 09:38:30 +1000

Ash and Tom doing the SMLM-AFM thing!

Photo

Fri, 03 Mar 2017 00:00:00 +1100

More studes!

Wed, 10 Feb 2016 00:00:00 +1100

Ash and Riley are in for Honours

H1s all round!

Sun, 15 Nov 2015 00:00:00 +1100

Congrats Lukas and Jason who nailed their honours theses and both got First Class. Well played!

New studes!

Tue, 10 Feb 2015 00:00:00 +1100

Lukas Jason and Ben join the group to do some super duper super-res stuff.

Merry Christmas.

Tue, 23 Dec 2014 17:42:01 +1100

Merry Christmas.

This week’s Australian Synchrotron User Meeting marked...

Sun, 23 Nov 2014 12:11:22 +1100

This week’s Australian Synchrotron User Meeting marked Donna’s fifth consecutive attendance and Toby’s first. Donna presented a talk debuting results from beamtime in August which combined SMLM and S-FTIR for the first time in order to examine both the structural and compositional makeup on single cells before and after fixation. The results went down well with a lot of positive feedback. The paper should be out soon!

scienceisbeauty: 2014 Nobel Prize in Chemistry goes to Eric...

Fri, 10 Oct 2014 09:27:19 +1100

scienceisbeauty:

2014 Nobel Prize in Chemistry goes to Eric Betzig (Janelia Farm Research Campus), Stefan W. Hell (Max Planck Institute for Biophysical Chemistry) and William E. Moerner (Stanford University)

for the development of super-resolved fluorescence microscopy

Congrats!

Press Release (PDF)

Popular Information (PDF: How the optical microscope became a nanoscope)

Advanced Information/Scientific Background (PDF: Super-resolved fluorescence microscopy)

A little bit more info on yesterday’s Nobel Prize! Several members of the lab were lucky enough to see both Stefan Hell and W.E. Moerner presenting their latest research just last month at the PicoQuant meeting.

Exciting News!

Thu, 09 Oct 2014 21:56:00 +1100

Exciting News!

Same cells, same fixative, same immunostaining protocol for...

Thu, 25 Sep 2014 00:00:00 +1000

Same cells, same fixative, same immunostaining protocol for microtubules but one little thing is making all the difference in the amount of non-specific stain localized using dSTORM. Details to come, hopefully in our soon-to-be-submitted protocols and artefacts paper.

We are back from Germany! After a quick detour to visit the...

Sat, 20 Sep 2014 00:00:00 +1000

We are back from Germany! After a quick detour to visit the Sauer lab in Wurzburg, Toby and Donna met up with Rosey and Heather in Berlin for the PicoQuant Single Molecule Workshop. Posters were presented with lots of good feedback and Toby gave the shortest talk of his life. It was fantastic to see so many different labs from all over the world presenting state-of-the-art fluorescence research and in between the onslaught of information that the conference provided many ideas for new and ongoing research projects were hatched. A river cruise in beautiful weather and dinner at the top of the Radio tower capped off a truly wonderful trip.

The first cell line we ever tried to image is back and yielding...

Wed, 03 Sep 2014 00:00:00 +1000

The first cell line we ever tried to image is back and yielding some stunning whole-cell 2D images of the actin network around the nucleus. The glutaraldehyde protocol we have specifically optimized for actin ultrastructure preservation has now been tested on three different mammalian cell lines, all with great results, and should be published as part of an upcoming paper.

Almost time for the 20th PicoQuant Single Molecule Workshop. Four posters will be present spanning...

Sun, 31 Aug 2014 18:38:00 +1000

Almost time for the 20th PicoQuant Single Molecule Workshop. Four posters will be present spanning nanocrystals to Rabies, pH sensors to imaging artefacts. Heather will be arriving in Berlin via Denmark along with Bell group alumni Emma Hooley who is now doing a postdoc at the University of Coperhagen. Rosey will be flying in direct from Melbourne. And Donna and Toby will be coming up from Wurzburg along with members of Markus Sauer’s group.

Certainly a good excuse to touch base with our dSTORM collaborators and revisit Wurzburg once more…

This week we had the pleasure of hosting several science-savvy...

Tue, 24 Jun 2014 00:00:00 +1000

This week we had the pleasure of hosting several science-savvy Year 10 work-experience students and were tasked with showing them how a working research lab operates. In between looking at the fluorescence of fingerprints and various dust samples from around the department, we also spent time checking and calibrating the pH of the stock solutions and imaging buffers in use with our favorite high-tech pH paper. Pretty cool work experience if you ask me.

Stretched DNA labelled using YOYO-1 and imaged on the home built...

Sun, 08 Jun 2014 00:00:00 +1000

Stretched DNA labelled using YOYO-1 and imaged on the home built super resolution setup with varying success. Ongoing work by Donna and Lukas has confirmed that sub-diffraction imaging of DNA is really, really, really hard but absolutely possible. Some great images have been captured. Sometimes, as in the middle, the DNA isn’t so well stretched or labelled. But other times, as in the top and bottom images, a magnitude-improved spatial resolution is demonstrated in the double strand cross-sections.

Photo

Fri, 23 May 2014 10:26:44 +1000

PicoQuant 20th Single Molecule Workshop - Berlin - September 2-5

Fri, 23 May 2014 10:22:00 +1000

20th International Workshop on
“Single Molecule Spectroscopy and Ultra Sensitive Analysis in the Life Sciences”

Abstracts have been submitted and registrations paid. Toby, Donna, Rosey and Heather are all excited to be heading to Germany for this fantastic meeting!

Link.

Fri, 23 May 2014 10:08:00 +1000

Link.

Fri, 23 May 2014 09:14:00 +1000

Link.